a16z Crypto Startup Accelerator (CSX)

Ambient

crypto

Ambient helps users access verified AI inference on a Solana SVM–compatible Proof of Work Layer‑1 blockchain.

Blocksense Network

crypto

Blocksense Network operates a zkRollup-based oracle protocol for verifiable data and compute. It provides programmable price feeds and oracle scripts for developers and blockchain networks, using secret-committee consensus and zero-knowledge proofs.

Cambrian Network

hybrid

Cambrian is an AI infrastructure protocol providing onchain and offchain data for automated financial decision-making. Through a decentralized network of validators, it transforms data into accessible financial intelligence, enabling developers to build AI and DeFi applications like alpha-generating agents, automated liquidity tools, and portfolio rebalancers.

Cork Protocol

crypto

Cork Protocol provides programmable, tokenized risk infrastructure for onchain assets. Its Cork Pools enable liquidity buffers, risk coverage, peg resilience, and protected looping for asset issuers, vaults, risk curators, and liquidity providers.

Embed

hybrid

Embed is a crypto-native AI recommendation platform for Web3 builders. It provides APIs and SDKs for personalized onchain asset feeds, smart-money notifications, and agent intelligence for wallets, trading apps, and prediction-market products.

Fermah

crypto

Fermah builds blockchain infrastructure for autonomous, verifiable workflow execution and zero-knowledge proof generation. Its products include Fermah Kernel, a trustless workflow execution engine, and Fermah Froben, a live universal ZK proof marketplace serving developers and protocols.

Hibachi

crypto

Hibachi is building a high-performance central limit order book (CLOB) for stablecoin foreign-exchange trading.

Inco

crypto

Inco helps users add confidentiality to smart contracts by enabling encrypted state and private compute on existing blockchains.

Inference

crypto

Inference is a distributed GPU network for running AI models efficiently across a global infrastructure.

KYD Labs

crypto

KYD Labs provides blockchain-based ticketing and financing infrastructure for live events, enabling venues and artists to control ticket sales and access upfront capital.

Launcher Capital

hybrid

Launcher Capital is a company pioneering the future of AI gaming by integrating AI agents with gamification and blockchain technology. They aim to redefine game creation and play through intelligent, evolving multi-agent systems.

Merit Systems

hybrid

Merit Systems builds products and developer tools for open agentic commerce. Its services help AI agents discover, pay for, and interact with APIs and other digital resources using protocols such as x402 and MPP.

MeshMap

crypto

MeshMap helps users discover and build XR experiences using an open 3D map, a Unity SDK, and APIs.

Neynar

crypto

Neynar is a developer platform that provides APIs, tools, and infrastructure for building applications on the Farcaster social protocol.

NodeKit

out of scope

NodeKit developed a composable network for Web3 rollups centered on Javelin, a shared block-building system for atomic cross-rollup transactions. The website states that NodeKit is currently in the process of shutting down.

Opacity Labs

crypto

Privately verify data from anywhere on the internet using zero-knowledge proofs powered by Opacity. Your users, their data, verified.

OpenLayer

crypto

Stealth

ORO

hybrid

ORO is a human intelligence protocol that allows users to get fairly compensated for contributing their private data to advance AI. Operated by Midcentury Labs Inc., the platform prioritizes user privacy and control through privacy-preserving technologies like zkTLS and TEEs, enabling users to earn points and token rewards for their data contributions, which are used to train AI models.

PIN AI

hybrid

PIN AI develops a privacy-focused personal AI platform and mobile assistant. Its products connect users’ personal data to on-device and cloud AI, enabling personalized agents, data ownership, and interactions across applications.

PrismaX

ai robotics

PrismaX provides a service layer for physical AI, connecting robot operation, human-in-the-loop data validation, and robotics-model development. Its VLA Foundry produces and verifies training datasets for robotics and AI companies.

Reflect Money

crypto

Reflect Money tokenizes DeFi strategies as interest-bearing US dollar stablecoins managed by decentralized programs rather than human operators.

Rumi Labs

ai robotics

Rumi Labs is building a decentralized Vision-Language Model (VLM) network that powers interactive media and contextual advertising. It focuses on helping AI understand human stories by analyzing millions of hours of IP media content that centralized AI labs cannot access, targeting media companies, advertisers, and content platforms.

Sablier

crypto

Sablier helps users distribute tokens onchain by providing streaming payment infrastructure for vesting, payroll, and airdrops.

Scrypted

hybrid

Scrypted is developing decentralized AI agents, referred to as Autonomous Virtual Beings (AVBs), and the Inori Network to support them. Their approach leverages blockchain technology, viewing fully on-chain autonomous worlds as the perfect environment for emergent AI.