DeScier develops an open scientific infrastructure centered on decentralized funding, shared laboratory instruments and protocols, reproducible experiments, and author-owned scientific publishing. Its model uses mechanisms such as quadratic funding, retroactive grants, research DAOs, tokenized milestones, open peer review, on-chain provenance, shared instrumentation, versioned protocols, and open datasets. DeScier focuses on scientists, citizen researchers, reviewers, engineers, independent labs, universities, research DAOs, open-access journals, funders, and broader scientific communities.